Why, then, have scores of drugs, previously found to be effective in animal models, failed clinical trials? The average clinician will answer this question by saying that animal experiments are useless, that they do not reflect the human situation, that they are badly designed and carried out, and so forth. Meetings and committees have even been celebrated to declare this truth, and to teach preclinical neuroscientists how to properly carry out their experiments, see for example the “STAIR” (Stroke Therapy Academic Industry Roundtable) meetings in the US
