In this chapter, the focus on modelling the feedback dynamics of DNA methylation is dealt with in four parts, consisting of: (1) DNA Methylation mechanisms, controlling factors – DNA sequence pattern analyses and Histone modifications and their association with disease initiation, (2) A background on the recent data explosion, multiple methods and modelling approaches developed so far to investigate DM mechanisms and associated factors, (3a) Description of methods to investigate CG distribution in human DNA sequences – Results obtained and their association with DM spread, (3b) Developments on a novel micromodel framework, (based on MCMC) used to investigate Histone modifications for different DM levels and, (4) Results obtained.
