This chapter discusses the problematic nature of interfacial sciences when constrained to the mesoscale. Interfacial sciences are trapped between the atomistic and the three- dimensional bulk regimes - the mesoscale. We experience a breakdown of phenomenological descriptions used to characterize macrosystems. Furthermore, submicrometer systems with their fractal-like dimension cannot be adequately described with quantum or molecular interaction theories. The challenge of describing the mesoscale for the.
