With rapid advancements in computing power, computer modeling and simulations have become an important complement to experimentations in many areas of research as well as industrial applications. The Discrete Event Simulation (DES) method has received widespread attention and acceptance by both researchers and practitioners in recent years. The range of application of DES spans across many different disciplines and research fields. In research, further development and advancements of the basic DES algorithm continue to be sought while various hybrid methods derived by combining DES with other simulation techniques continue to be developed. This book presents state-of-the-art contributions on fundamental development of the DES method, novel integration of the method.