Although the technologies on chiral/enantiomer separation and stereoselective analysis have matured in the past ca. 20 years, the development of new, even more advanced chiral separation materials, mechanisms and methods still belong to the more challenging tasks in separation science and analytical chemistry. An analysis of recent trends indicates that capillary electrophoresis (CE) can show real advantages over chromatographic methods in ultratrace chiral determination of biologically active ionogenic compounds in complex matrices, including mostly biological ones