The third edition of Principles of Tissue Engineering attempts to incorporate the latest advances in the biology and design of tissues and organs and simultaneously to connect the basic sciences — including new discoveries in the field of stem cells — with the potential application of tissue engineering to diseases affecting specific organ systems. While the third edition furnishes a much-needed update of the rapid progress that has been achieved in the field since the turn of the century, we have retained those facts and sections that, while not new, will assist students and general readers in understanding this exciting.