Fatty acids are an important energy source, for they yield over twice as much energy as an equal mass of carbohydrate or protein. In humans, the primary dietary source of fatty acids is triacylglycerols. This lecture will describe the metabolism of fatty acids. The two main components of fatty acid metabolism are β oxidation and fatty acid synthesis. Upon completion of this lecture, you will understand that the fatty-acid breakdown reactions of β oxidation result in the formation of reduced cofactors and acetyl-CoA molecules, which can be further catabolized to release free energy. You will also understand that the oxidation. | CHAPTER 5. LIPID METABOLISM INTERNATIONAL UNIVERSITY SCHOOL OF BIOTECHNOLOGY BIOCHEMISTRY Learning objectives Describe the metabolism of fatty acids. The two main components of fatty acid metabolism are β oxidation and fatty acid synthesis. Understand that the fatty-acid breakdown reactions of β oxidation result in the formation of reduced cofactors and acetyl-CoA molecules, which can be further catabolized to release free energy. Understand that the oxidation of unsaturated, odd-chain, and very-long-chain fatty acids requires additional enzymes, some of them in peroxisomes. Understand how fatty acid synthesis resembles and differs from β oxidation. Content 1. Fatty acid activation 2. Steps of β oxidation 3. Energy yield of oxidation 4. Oxidation of palmitate 5. Unsaturated fatty acids 6. Odd-chain fatty acids Content 7. Very long-chain fatty acids 8. Synthesis vs. oxidation 9. Steps of synthesis 10. Palmitate synthesis 11. Fatty acid synthases Conclusion Fatty Acid . | CHAPTER 5. LIPID METABOLISM INTERNATIONAL UNIVERSITY SCHOOL OF BIOTECHNOLOGY BIOCHEMISTRY Learning objectives Describe the metabolism of fatty acids. The two main components of fatty acid metabolism are β oxidation and fatty acid synthesis. Understand that the fatty-acid breakdown reactions of β oxidation result in the formation of reduced cofactors and acetyl-CoA molecules, which can be further catabolized to release free energy. Understand that the oxidation of unsaturated, odd-chain, and very-long-chain fatty acids requires additional enzymes, some of them in peroxisomes. Understand how fatty acid synthesis resembles and differs from β oxidation. Content 1. Fatty acid activation 2. Steps of β oxidation 3. Energy yield of oxidation 4. Oxidation of palmitate 5. Unsaturated fatty acids 6. Odd-chain fatty acids Content 7. Very long-chain fatty acids 8. Synthesis vs. oxidation 9. Steps of synthesis 10. Palmitate synthesis 11. Fatty acid synthases Conclusion Fatty Acid Metabolism LEARNING OBJECTIVES Fatty acids are an important energy source, for they yield over twice as much energy as an equal mass of carbohydrate or protein. In humans, the primary dietary source of fatty acids is triacylglycerols. This lecture will describe the metabolism of fatty acids. The two main components of fatty acid metabolism are β oxidation and fatty acid synthesis. Upon completion of this lecture, you will understand that the fatty-acid breakdown reactions of β oxidation result in the formation of reduced cofactors and acetyl-CoA molecules, which can be further catabolized to release free energy. You will also understand that the oxidation of unsaturated, odd-chain, and very-long-chain fatty acids requires additional enzymes, some of them in peroxisomes. In addition, you will understand how fatty acid synthesis resembles and differs from β oxidation. FATTY ACID ACTIVATION Triacylglycerols are carried by lipoproteins to tissues, where hydrolysis releases their .
