Positron emission tomography (PET), a powerful research tool 20 years ago, has recently gained widespread application in oncology and is now a procedure clinically available on each continent. Despite the fact only a few PET centers are dedicated to children, data from Children’s Oncology Group indicate that virtually all children in North America have easy access to a PET center. As the table of contents of this book indicates, clinical and research applications of PET for children with cancer represent only a fraction of the current pediatric uses for PET technology. Small animal PET scanners are now available commercially as there has been tremendous interest in applying PET technology.