For this reason, levels of mental distress among communities need to be understood less in terms of individual pathology and more as a response to relative deprivation and social injustice, which erode the emotional, spiritual and intellectual resources essential to psychological wellbeing. While psycho- social stress is not the only route through which disadvantage affects outcomes, it does appear to be pivotal. Firstly, psychobiological studies provide growing evidence of how chronic low level stress ‘gets under the skin’ through the neuro-endocrine, cardiovascular and immune systems, influencing hormone release . cortisol, cholesterol levels, blood pressure and inflammation . C-reactive proteins. Secondly, both.