Topics also aim to exploit progress in the development of innovative protein binding scaffolds as alternatives to classical antibodies and oligo-nucleotides. Substantial involvement of SMEs is also required. Immunisation is addressed through a high-impact initiative that aims to apply advanced technologies to the development of new immunisation strategies. For international cooperation, a topic concerned with therapy of chronic inflammatory autoimmune diseases with participation of Brazilian teams is described. Note: Depending on the topics listed below, applicants should follow the rules for single or two-stage submission procedure (see also respective call fiche in section III). .