Medications can also interact with what we eat or drink, or with our activities. We may never notice many of these interactions. They might not affect how we feel or function. Ask your doctor or pharmacist if it’s safe to drink alcohol when taking your medications. Ask about each drug you take, whether prescription or non-prescription. Many drugs, even over-the-counter drugs and herbal supplements, interact dangerously with alcohol. Even a small amount of beer, wine, or liquor can change how a drug works in your body. Alcohol can get in the way of your medicine doing what it is.