Currently only a few European centres are able to deal with the large volume of omics data. At omics level, the challenges include storage, handling and integration of large volumes of data necessitating efforts on data standardisation and the introduction of innovative informatics solutions. Current medical coding systems are generally reimbursement-driven and are therefore of limited value for research studies. The development of a clinically more relevant medical coding system for research and the design and validation of algorithms and statistical methods for the analysis of multiple layers of omics data is required. Internet portals with “ready-for-use” applications to.