Before embarking on policy reforms to improve access, national policy-makers need to have a clear understanding of the factors that are contributing to high prices and poor avail- ability; this will help ensure that their response is tailored to the national context. Table lists a number of possible policy options and specific actions that are open to governments for reducing prices and improving availability. The most appropriate response will likely be multi-faceted and will vary depending on the sector, whether the medicine is imported or locally manufactured and whether it is a single-source originator brand product or a multi- source generic.