We present the proceedings from the workshop entitled Scientific Detectors for Astronomy 2005, a weeklong meeting held in Taormina, Sicily during 19-25 June 2005. This was the sixth workshop of this series, and the fourth with hardcover proceedings. By all measures, this workshop surpassed the previous meetings. The primary purpose of any technical meeting is the exchange of scientific and engineering information. The meeting was attended by 127 astronomers, scientists and engineers from 21 countries spread across every continent, with representation of all major manufacturers and 36 astronomical observatories. A total of 94 oral and poster papers were presented, of which 87 are contained in these proceedings