In its fifth edition, Cancer Medicine has been named eponymously to honor its founding editors James F. Holland and Emil Frei III, two giants of medical oncology. The Holland-Frei Cancer Medicine reflects their dedication to innovative, comprehensive, and multidisciplinary care of cancer patients, as well as their belief in the importance of grounding such care in a more fundamental understanding of cancer biology. It is to their vision and the example that they have established over the last four decades that this book is dedicated. From edition to edition, Cancer Medicine has appeared at increasingly shorter intervals. The fifth edition follows the fourth by just three and.