Medicine, health care and the wider social meaning and management of health are undergoing major changes. In part, this reflects developments in science and technology, which enable new forms of diagnosis, treatment and the delivery of health care. It also reflects changes in the locus of care and burden of responsibility for health. Today, genetics, informatics, imaging and integrative technologies, such as nanotechnology, are redefining our understanding of the body, health and disease; at the same time, health is no longer simply the domain of conventional medicine, nor the clinic