In this paper, participants in the Translational Medicine task force of the World Wide Web Consortium’s Health Care and Life Sciences Interest Group (W3C HCLSIG) present the Translational Medicine Ontology (TMO) and the Translational Medicine Knowledge Base (TMKB). The TMKB consists of the TMO, mappings to other terminologies and ontologies, and data in RDF format spanning discovery research and drug development, which are of therapeutic relevance to clinical research and clinical practice. The TMO provides a foundation for types declared in Linking Open Drug Data (LODD) [21] and EHRs. The TMO captures core, high-level termi- nology to bridge existing open domain ontologies and provides a framework to relate and.