Bioinformatics is an emerging and rapidly growing area of science. Not sur- prisingly, there is tremendous lag time between the state of knowledge and the publication of manuals for those who need to fathom the basic knowledge and apply it in problem solving. Mr. Rashidi and Dr. Buehler have found a way to address these needs. Their book provides excellent, timely, and easy- to-understand information and advice for those without a great.