Therefore, more than 100 research hypotheses were examined during the planning stage, and as a result, the following core hypothesis topics have been established (Figure 2). The core study hypotheses were examined and proposed by working groups established by a federal advisory group. The topics of the core hypotheses can be roughly divided into pregnancy, birth, reproduction, children’s physical and mental development, asthma, obesity, injury, their relationship to exposure to environmental pollutants and social factors such as family and neighborhood characteristics, and also the interactions between these factors and genetic factors. In other words, the National Children’s Study covers.