Various systemic diseases (systemic vasculitis-systemic lupus erythematosis, Henoch-Sch¨ onlein purpura, hemolytic ure- mic syndrome, sickle cell disease, and malignancy) and syn- dromes (chromosomal aberrations, Rubinstein-Taybi, Cor- nelia de Lange, and many others) may affect the kidney in childhood [1]. Renal involvement should be excluded in any individual with multisystem disease (collagen disease, diabetes mellitus, and storage diseases). Systemic diseases associated with glomerular abnormalities may present with arthritis, rash, hypertension, hematuria, or proteinuria. The diagnosis of renal involvement in systemic disease is based on clinical findings (hematuria, proteinuria, hypertension, and decreased serum complement levels, decreased renal function)aswellasrenalhistology
