Yes. Local anesthetic with epinepherine can be used during pregnancy. Lidocaine with epinephrine is considered safe during pregnancy. Lidocaine (2%) is a category B drug in contrast to mepivicaine (3%) which is a category C drug. Lidocaine with epinephrine prolongs the length of anesthesia because the drug is absorbed slowly. There is a theoretical concern about the effect of epinephrine on uterine muscle. No scientific studies, however, could be found to confirm this effect in pregnant women. The frequency of malformations was not increased among reviews of almost 300 children whose mothers were given lidocaine during early pregnancy (11;13)
