This report confirms that approximately one-quarter of the global disease burden, and more than one-third of the burden among children, is due to modifiable environmental factors. The analysis here also goes a step further, and systematically analyzes how different diseases are impacted by environmental risks and by 'how much.' Heading that list are diarrhoea, lower respiratory infections, various forms of unintentional injuries, and malaria. This 'environmentally-mediated' disease burden is much higher in the developing world than in developed countries - although in the case of certain non-communicable diseases, such as cardiovascular diseases and cancers, the per capita disease burden is larger in developed countries. Children bear the highest death toll.