In a certain sense, the field of drug metabolism (DM) is standing still. More specifically, the basic experiment of drug metabolism (., administering a new drug to an animal or human and determining the structures, amounts, and disposition of the metabolites) has changed very little over a period of decades. Remarkably, the experimental design and resulting data set from a typical absorption, distribution, metabolism, and excretion (ADME) study conducted today would be instantly recognized and understood by DM scientists from 50 years ago. This is not the case with most other disciplines in the life sciences
