The extracellular matrix (ECM) represents a complex organization of macromolecules that surrounds the cell and comprises the substratum onto which the cell may be attached. The properties and functions of the ECM depend ultimately on its structure, molecular components, architecture, and dynamic modulation. Because the critical role of ECM involved in cell biology and physiology has long been recognized, the structure and biology of the ECM have been extensively studied (Yurchenco and Birk 1994 ; Ayad et al. 1998 ; Robert 2001 ) . The diversity found in the structure and organization of the ECM appears to be tissue specifi c and regulates the properties and function of.
