The idea for The Phylogenetic Handbook was conceived during an early edition of theWorkshop on Virus Evolution andMolecular Epidemiology. The rationale was simple: to collect the information being taught in the workshop and turn it into a comprehensive, yet simply written textbook with a strong practical component. Marco and Annemie took up this challenge, and, with the help of many experts in the field, successfully produced the First Edition in 2003. The resulting text was an excellent primer for anyone taking their first computational steps into evolutionary biology, and, on a personal note, inspired me to try out many of the techniques introduced by the book in my.