NASA’s exploration of planets and satellites over the past 50 years has led to the discovery of water ice throughout the solar system and prospects for large liquid water reservoirs beneath the frozen shells of icy bodies in the outer solar system. These putative subsurface oceans could provide an environment for prebiotic chemistry or a habitat for indigenous life. During the coming decades, NASA and other space agencies will send flybys, orbiters, subsurface probes, and, possibly, landers to these distant worlds in order to explore their geologic and chemical context and the possibility of extraterrestrial life. Because of their potential to harbor alien life, NASA will.