The aim of this study was to assess the effects of Pomelo (Citrus grandis (L.) Osbeck) peel extracts (CGE) on activity of lipid-carbohydrate metabolic enzymes such as Carnitine pamitoyl-transferase (CPT), lipase, hexokinase, glucose 6-phosphatase and blood lipid glucose parameters in experimental obese and diabetic mice. The results showed that, in the experimental obese mice treated daily, orally with CGE at dose of 1200 mg/body weight for three weeks,