CKD in children is the result of heterogeneous diseases of the kidney and urinary tract that range from common congenital malformations of the urinary tract, to rare inborn errors of metabolism that affect kidney function[1] . CKD is an irreversible condition that eventually progresses to end stage renal disease (ESRD). It is an important cause of morbidity and mortality in children worldwide [2,3] . The causes of CKD vary from one geographic area to another due to genetic and environmental factors. Some of these causes are preventable while in others, appropriate medical treatment and interventions may retard the progression of the disease [2] . In the absence of a national registry, there is paucity of information regarding the etiology of CKD in children from Iran[4] . An understanding of the causes of CKD is important as it may guide the distribution of limited resources towards its prevention. The aim of the present study was to determine retrospectively the etiology of CKD in children referred to our center. .