For older adults who experience depression for the i rst time later in life, other factors, such as changes in the brain or body, may be at play. For example, older adults may sufer from restricted blood low, a condition called ischemia. Over time, blood vessels become less l exible. hey may harden and prevent blood from l owing normally to the body’s organs, including the brain. If this occurs, an older adult with no family or personal history of depression may develop what some doctors call “vascular depression.” hose with vascular depression also may be at risk for.