SSRIs and SNRIs tend to have fewer side ef ects and are more popular than the older classes of antidepressants, such as tricyclics—named for their chemical structure—and monoamine oxidase inhibitors (MAOIs). However, medi cations afect everyone dif erently. here is no one-size its-all approach to medication. herefore, for some people, tricyclics or MAOIs may be the best choice. People taking MAOIs must adhere to signiicant food and medicinal restrictions to avoid potentially serious inter actions. hey must avoid certain foods that contain high levels of the chemical tyramine, which is found in many cheeses, wines and pickles, and some medications includ ing.