Results of a comprehensive review of pediatric trials con ducted between 1988 and 2006 suggested that the benei ts of antidepressant medications likely outweigh their risks to children and adolescents with major depression and anxiety disorders. he study was funded in part by the National Insti tute of Mental Health. 31 Also, the FDA issued a warning that combining an SSRI or SNRI antidepressant with one of the commonly-used “triptan” medications for migraine headache could cause a life-threatening “serotonin syndrome,” marked by agitation, hallucinations, elevated body temperature, and rapid changes in blood pressure. Although most dramatic in the case of the MAOIs,.