Penetrating the lesion: Fixing the lesion with one hand, grasp the syringe with the needle attached (with or without syringe holder) by the dominant hand and introduce through the skin into the lesion, carefully and swiftly. The angle and depth of entry varies with the type of lesion. For small lesions, aspiration of central portion is indicated. For larger lesions that may have necrosis, cystic change or hemorrhage in the center, aspiration may be done from the periphery. If pus or necrotic material alone is aspirated from larger lesions, FNA can be repeated immediately from the periphery. With experience, a change in tissue consistency will be felt.
