Nongynecological cytology specimens are collected from a variety of sites for the detection of malignant and benign processes. The site from which the sample is collected dictates the method of collection. The method of collection affects the morphology of the cellular samples. The importance of proper specimen collection and submission is essential. Clinical personnel should be trained in the appropriate submission of samples as well as in procedural techniques. The laboratory must provide instructions for proper collection of all nongynecological specimens. The instructions must be available to personnel at the location where the specimens are.