The significance and potential of the protocol go well beyond Africa. The treaty affirms reproductive choice and autonomy as a key human right and contains a number of global firsts. For example, it represents the first time that an international human rights instrument has explicitly articulated a woman’s right to abortion when pregnancy results from sexual assault, rape, or incest; when continuation of the pregnancy endangers the life or health of the pregnant woman; and in cases of grave fetal defects that are incompatible with life. Another first is the protocol’s call for the prohibition of harmful.