Coastal zone of Cuu Long estuary is a place through which Mekong River flows into the Eastern Sea with 8 estuaries. is the zone is formed under the influences in the interaction between river and sea. Geologically, coastal zone of Mekong delta is characterised by the predominat of clay and silt formations. These two factors makes the shoreline sensitive to exogenous processes such assedimentation and erosion This paper presents an application of satellite remote sensing technology to detect and analyze the spatial changes as well as quantify the shoreline change in Cuu Long estuary. Landsat and Aster satellite images were.