This study investigates impacts of climate change on water resource in the Huong River basin in the Central Vietnam. Hydrological responses of six climate change scenarios were calculated. Results reveal that climate change would cause significant increase in rainfall in wet season resulting in an increase in river flow. By contrast, the decreasing trend of river flow in dry season is a consequence of the decline of rainfall and increase of evapotranspiration under most scenarios. Sea level rise coupled with the lowering of river stages may exacerbate salinity intrusion. Impacts of climate change on socio-economic sectors such as agriculture,.