Reusing domestic wastewater for irrigation is a common practice in peri-urban areas in Vietnam. This study investigates the characteristic of domestic wastewater in Hanoi City in terms of nutritive value and potential risk in using for agriculture. The wastewater samples were collected in four main drainage rivers of the City including Lu, Set, Kim Nguu, and To Lich River during March to May 2010. We found that the wastewater of Hanoi City