In recent decades, the increasing in greenhouse gas emission has caused global warming leading to many adverse changes of the environment especially the sea level rise and the hydrological regime. The Dong Nai river basin having the downstream part below the sea level is among the most vulnerable basins to climate change. Recents studies showed that the sea level in the downstream of Sai Gon - Dong Nai river basin is rising. Many cities downstream of the basin especially Ho Chi Minh city are being flooded in flow tides which seriously affect the socioeconomic development. Thus, research on the.