People are motivated to use ART to have a genetically related child, and circumstances vary widely: couples in which one person is infertile; 4 lesbian couples; gay male couples; a couple in which one or both partners are transgender; single straight, queer and trans women and men; women undergoing chemotherapy; women who want to delay childbearing; and couples who want to use pre-implantation genetic diagnosis (PGD) to screen against disability or for sex. As genetic screening becomes more popular, affordable, and able to test for a greater number of characteristics, it is possible that more people who are not infertile.