For those using ART because of medical infertility, there are a variety of factors that can contribute to this diagnosis. According to the Collaborative on Health and the Environment, infertility can be caused by genetic or environmental factors, combinations of the two, or endocrine or immune system disorders. It can be caused in the womb, in which genetic instructions are impacted by factors such as a mutation, a chemical insult, or an imbalance in hormones and the impact is not seen until the individual tries to procreate; or it can be caused in adulthood. 20-40% of infertility is due to.