Amphetamine synthesized 1887 by German chemist, L. Edeleano Methamphetamine was first produced by Dr. Nagayoshi Nagiai of Tokyo Imperial University in 1888 by reducing ephedrine with HI & Red Phosphorus Methamphetamine synthesized from methylamine and phenyl-2-propoanone 1919 by Japanese researcher, A. Ogata Early 1900s: Western civilization discovers benefits of ephedrine and pseuodephedrine as brochodilators and nasal decongestants. Fear that ma huang plants will run out (source for the herb ephedra). 1927 (USA): Researcher Gordon Alles discovers that amphetamine works as a substitute for ephedrine. Amphetamine starts being synthesized as substitute for ma huang. 1930: Amphetamine discovered to increase blood.
