Copper fungicides are environmentally unfriendly. They are very toxic to fish and aquatic invertebrates, such as crab, shrimp and oysters. There are cases where most animal life in soil, including large earthworms, have been eliminated by the extensive use of copper-containing fungicides in orchards. It is strongly bioaccumulated and is very persistent. Once a soil is contaminated with copper, there is no practical way to remove it. The organic insecticide rotenone has been found to be toxic to pigs, rats and dogs and is is very toxic to fish. It causes skin and eye irritations. Inhalation of the dust causes respiratory problems and convulsions in.