Volume 3 of the book series Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems aims at presenting major sets of signaling receptors mainly located at the plasma membrane, 1 in a modeling framework rather than biological perspective. Collecting signaling effectors, their main interactions, and major properties are the first tasks required for any modeling of cell signaling processes. The major objective is to comprehend the complexity of natural phenomena to model these events. In other words, to yield the maximal amount of known information (., to briefly describe the huge number of signaling mediators and their main known features) enables the depiction of any signaling cascade using.