This study was designed to help mothers improve their personal habits and to make the best use of available first aid treatment for minor ailment. Although health education interventions have been carried out in several study settings [6,10,11] few have considered the effect of multiple interventions on attitude, knowledge, and treat- ment seeking behavior of mothers of under–5 s. This study was therefore designed to determine the effect of health education on the home management of malaria among the mothers of under-5 s in Ogun State, Nigeria. Primary healthcare as stated in the Alma Ata declaration underscores the importance of health education as one of the key methods of preventing and controlling.