Since this book was first published in 1998, there have been significant advances in our understanding of the morphology of the skin and the properties that govern the transport of molecules into and across the three major strata. The multitude of data that has been generated has allowed the development of predictive models for both the rate and extent of dermal absorption and has increased our ability to predict the likelihood of local toxic events subsequent to solute penetration and permeation. In this second edition we have completely revised and updated many of the chapters that appeared in the earlier version and we have expanded the scope.
