It is a great pleasure to introduce volume 19 of the book series Monographs in Human Genetics entitled ‘Craniosynostoses: Molecular Genetics, Principles of Diagnosis and Treatment’. The initial idea for this book was born during a workshop on craniosynostoses held at the Academy of Human Genetics in Würzburg (Germany). Hartmut Collmann and Wolfram Kress brought together many seemingly diverse aspects of craniosynostoses, including clinical approaches, genetics, molecular mechanisms and, most importantly, treatments. As that course progressed, they realized how inspiring this subject was to their colleagues and medical students