Diseases of the neuromuscular junction (NMJ) include a large spectrum of acquired and inherited disorders mainly characterized by fluctuating muscle weakness and fatigability of ocular, bulbar or limb muscles. Remarkable progress has been made in our understanding of the pathogenesis of these disorders in recent years. Furthermore, our ability to diagnose these conditions has improved significantly due to the widespread availability of immunologic tests, the use of in vitro electrophysiologic and microstructural studies, and the refinement of sensitive clinical electrodiagnostic tests of neuromuscular transmission. Despite these advances, significant questions remain to be answered by the researcher and the clinician, and disagreement exists amongst specialists regarding therapy and management of patients. This.
