Masaki Okumura1,2, Masatoshi Saiki2,3, Hiroshi Yamaguchi1 and Yuji Hidaka2 1 School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan 2 Graduate School of Science and Engineering, Kinki University, Osaka, Japan 3 Department of Applied Chemistry, Faculty of Engineering, Tokyo University of Science, Yamaguchi, Japan Keywords arginine; disulfide; folding; glutathione; uroguanylin Correspondence Y. Hidaka, Graduate School of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan Fax: +81 6 6723 2721 Tel: +81 6 6721 2332 E-mail: yuji@ (Received 20 October 2010, revised 18 January 2011, accepted 28 January 2011) doi: Protein folding occurs simultaneously with disulfide bond formation. In general,.