Early breast cancer is subdivided into two major categories, in situ disease, mainly in the form of ductal carcinoma in situ (DCIS), and invasive cancer. Both are heterogeneous processes with very variable appearances, biology and clinical behaviour. Over recent years there have been important developments in the investigation and management of breast cancer including new types of chemotherapy, and biological and hormonal agents. There is some evidence of practice variation across the country and of inconsistent availability of certain treatments and procedures. This clinical guideline helps to address these issues and offers guidance on best practice. .