This updated edition of Improving Outcomes in Breast Cancer is based on the Manual published by the Department of Health in 1996. Additional material, based on recent reviews of research evidence and discussions by a reconstituted Editorial Group, has been inserted in a larger font size (12 point as opposed to 10 point) so that it can be distinguished from earlier text. In the original guidance references were given at the end of each section, these have been retained in this document. For the updated material footnotes have been used throughout the text to avoid confusion